Virtual Physiology

the unique truly simulation software


physiology and pharmacology experiments
in virtual laboratories
almost like in the real world
- Perfect for online teaching and remote learning -

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A brilliant neurosurgeon saves a young boy’s life, only to realize years later that he may have saved a monster. It is a slow-burn, grounded psychological thriller set in Germany.

It broke the internet. Twice. The vibe: Gory, unhinged, surprisingly heartfelt.

Adult manga aggregators rely heavily on aggressive advertising networks. Users often encounter intrusive pop-ups, forced redirects, and deceptive download links that attempt to install malware or tracking cookies on devices.

I should not write an article promoting or facilitating access to hentai content, especially using popular series like Naruto. My guidelines prohibit generating sexually explicit material. I need to politely explain that I cannot fulfill this request and state the reason clearly.

| Series | Genre | Unique Appeal | |--------|-------|---------------| | (Anime & Visual Novel) | Time Travel, Thriller | Slow-burn first half, then intense psychological rollercoaster. | | Made in Abyss (Anime & Manga) | Dark Fantasy, Adventure | Cute art hides brutal, existential horror. Incredible world depth. | | Dorohedoro (Manga & Anime) | Dark Fantasy, Gory Comedy | Unique art style, morally grey characters, chaotic fun. | | 86 EIGHTY-SIX (Anime & Light Novel) | Mecha, War Drama | Emotional, anti-war, stunning direction and sound design. | baca komik naruto hentai tsunade hinata sakura tenten top

| If you liked... | Try this... | Format | | :--- | :--- | :--- | | Demon Slayer | Hell’s Paradise | Anime/Manga | | Spy x Family | The Way of the Househusband | Manga/Netflix | | My Hero Academia | Undead Unluck | Manga | | Frieren | Witch Hat Atelier | Manga (anime soon!) | | Death Note | Tomodachi Game | Manga |

Sometimes you just want a story that feels like a warm hug or explores the complexities of everyday relationships.

The creation and consumption of these comics operate within a well-established global ecosystem. 1. The Role of Doujinshi Culture

The top-tier creators in the doujinshi community often mimic Kishimoto's original art style with incredible accuracy, making the alternative stories feel oddly familiar to long-time fans. A brilliant neurosurgeon saves a young boy’s life,

Thorfinn, a young Viking, grows up on the battlefield seeking revenge against the mercenary leader who murdered his father. The story evolves from a violent revenge epic into a profound philosophical exploration of pacifism.

Sakura's relationships with her teammates, particularly Naruto and Sasuke, are complex and multifaceted. Her bond with Tsunade, whom she admires and respects, also plays a significant role in her development as a character.

The current landscape of anime and manga is a mix of long-awaited sequels, highly-anticipated new adaptations, and legendary series entering their final chapters. For Spring 2026

The in the mainstream manga industry

By exploring these characters and their interactions, fans can gain a deeper understanding of the Naruto universe and appreciate the complexities of the series. Whether you're a longtime fan or new to the world of Naruto, there's no denying the appeal and inspiration of these remarkable characters.

| | Title | Genre | 2025 Sales / Why It's Popular | | :--- | :--- | :--- | :--- | | 1 | One Piece | Action, Adventure, Fantasy | 4.21 million copies sold ; returned to the #1 spot for the first time in six years | | 2 | Jujutsu Kaisen | Dark Fantasy, Supernatural | 3.92 million copies sold ; maintains strong influence in the action-supernatural genre | | 3 | Dan Da Dan | Supernatural, Sci-Fi, Rom-Com | 3.52 million copies sold ; combines aliens, ghosts, and romance in a wild story | | 4 | Blue Lock | Sports (Soccer), Thriller | 3.01 million copies sold ; features a rigorous training philosophy focusing on the ego of strikers | | 5 | Kingdom | Historical Epic, War | 2.5 million copies sold ; set in China's Warring States period, this seinen epic gained more international traction | | 6 | Blue Box | Romance, Sports (Badminton, Basketball) | 2.3 million copies sold ; tells a story of a love triangle and athletic struggles at school | | 7 | Sakamoto Days | Action, Comedy | 2.3 million copies sold ; the action choreography is unmatched and is a fan favorite | | 8 | The Apothecary Diaries | Mystery, Medical Drama, Romance | 2.2 million copies sold ; about a young woman solving medical mysteries in a royal court | | 9 | My Hero Academia | Superhero, Action | 2.0 million copies sold ; only released one volume, but its final volume was a major event for fans | | 10 | Fragrant Flower | Romance | ~1.5 million copies sold ; popular romance series that continues to gain readers |

| Manga (anime may exist) | Genre | Why It’s Exceptional | |------------------------|-------|----------------------| | (Manga – incomplete) | Dark Fantasy, Tragedy | Masterpiece of art and storytelling. Themes of trauma, willpower, and fate. Caution: very violent. | | Vinland Saga (Anime & Manga – ongoing) | Historical, Drama | Evolves from revenge epic to philosophical exploration of peace and purpose. | | Vagabond (Manga – on hiatus) | Samurai, Philosophical | Based on Miyamoto Musashi. Gorgeous art, deep meditation on strength and ego. | | Oyasumi Punpun (Manga only) | Psychological, Literary | Harrowing coming-of-age story. Not for light reading but unforgettable. |

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running on all Windows platforms,
from Win 7 to Win 11, 32 bit as well as 64 bit versions
without any specific requirements (see Technical Specifications)

including platform-independent Online Versions
for experiments via the Virtual Physiology server
existing so far for SimHeart and SimVessel
with beta-versions of SimMuscle and SimNeuron

SimHeart©

SimHeart offers a virtual laboratory for recordings of heart contractions in the Langendorff set-up in response on the most relevant transmitters and drugs, including a drug laboratory for the adjustment of the appropriate solutions.

Featured experiments:

  • Effects of Adrenaline and Acetylcholine on frequency and amplitude of heart contractions (inotroph and chronotroph effects)
  • Effects of competitive receptor blockers Propranolol and Atropine
  • Aadrenaline dose-response curve and its shift by the ß-blocker Propranolol (competitive inhibition)
  • Comparison with non-competitive inhibition by the Ca2+-channel blocker Verapamil
  • Strengthening of the contractions by the heart-glycoside g-Strophantine
  • Induction and treatment of arrhythmias and heart blocks in systole and diastole

SimVessel©

SimVessel offers a virtual laboratory for the examination of smooth muscle contractions of vessels and the intestine.
The experiments can be done with muscle stripes, placed in an organ bath to which physiologically relevant signal substances and widely used drugs can be added. Preparing the appropriate dilutions can be trained, as in SimHeart, in a drug laboratory.

Featured experiments:

  • Comparison of phasic and tonic smooth muscle contractions.
  • Illustrating the effects of muscle stretching (Bayliss effect)
  • Demonstrating opposite reactions of vessels and intestine on Adrenaline and Acetylcholine
  • Examining the effects of the cholinergic receptor antagonist Atropine
  • Comparing the effects of adrenergic α- and β-receptor antagonists (Phentolamine and Propranolol)
  • Illustrating the effects of the Ca2+-channel blocker Verapamil
  • Recording of dose-response curves of Adrenaline and Acetylcholine
  • Demonstrating alterations of dose-response curves by competitive and non-competitive inhibitors

SimMuscle©

SimMuscle offers a fully equipped, realistically appearing laboratory on the computer screen to perform classical experiments with isolated nerve-muscle preparations of the frog.
All stimulation and recording parameters of the virtual devices are freely adjustable. Mathematical algorithms guarantee for the appropriated reactions of the virtual muscle, also considering the biological diversity of the preparations.

The virtual “SimMuscle” laboratory contains two nerve-muscle preparations and all the apparatus that you will need for experimentation in a simplified but quite realistic form.

When entering the lab you first need to switch on all the devices (POWER buttons). Then drag one of two already prepared nerve-muscle preparations from the Petri-dish to hang it in the suspension apparatus. This includes a mechano-electrical converter transforming changes of either the muscle force or muscle length, selectable by a toggle switch, into an electric potential. You can pre-stretch the muscle hanging one or more weights in the loop at which the muscle is fixed.

Muscle contractions are induced by current pulses delivered from a stimulation apparatus to the electrodes on which the nerve is placed. Stimuli as well as muscle contractions are displayed on a dual beam storage oscilloscope, appropriately displayed with accordingly adjusted voltage amplification and time base (via the rotary switches) and zero lines. Single or double pulses as well as trains of stimuli of selectable amplitude and intervals can be applied.

The example shows muscle contractions, here changes of the muscle length, in response to different trains of voltage pulses inducing isolated twitches, incomplete and complete tetanic contractions depending on the intervals in which the pulses are applied.

Featured experiments:

  • Single twitches and their stimulus dependencies (recruitement of motor units)
  • Superposition of single twitches, tetanic contractions, resting tension curves (pre-stretching)
  • Curves of isometric and isotonic maxima, muscle fatigue

for details see Tutorial and Protocol form

For your own experiments you can download
a fully functioning DEMO Version

SimNerv©

SimNerv offers a fully equipped, realistically appearing laboratory on the computer screen to perform classical experiments of compound action potential recordings from isolated preparations of the frog’s sciatic nerve.
All stimulation and recording parameters of the virtual devices are freely adjustable. Mathematical algorithms guarantee for the appropriated reactions of the virtual nerve, also considering the biological diversity of the preparations.

In the “SimNerv” laboratory you will find a stimulator, an oscilloscope, a recording chamber and a Petri dish with two already prepared nerves.

For your measurements take one of the nerves by mouse click out of the Petri-dish and place it on the electrodes in the recording chamber. The position of the electrodes can be changed and the temperature of the recording chamber can be adjusted. You can set a nerve ligature (fully reversible) using the thread.

The stimulator delivers voltage pulses to the stimulation electrodes. The stimulus is simultaneously displayed at channel 1 of the oscilloscope via a separate cable..AMPLITUDE and DURATION of the stimulus pulses can be adjusted as well as the DELAY between the onsets of two successive stimuli when TWIN pulses shall be applied (MODE). The POLARITY switch allows to invert the direction of the current flow, INVERT corresponds to an exchange of the stimulus electrode positions.

The simple double-beam storage oscilloscope displays the stimulus pulse (channel 1), simultaneously with the compound action potential (CAP, channel 2) measured as the potential difference between the two recording electrodes by means of a differential amplifier. The sensitivity of both oscilloscope channels (mV/DIV) as well as their common time-base (ms/DIV) can be adjusted via the rotary switches.

Featured experiments:

  • Stimulus-response curve: recruitment of nerve fibres on increasing stimulus amplitudes
  • Strength-duration curve, rheobase, chronaxy: the impact of stimulus duration
  • Refractory period and anode break potentials: physiological and clinical relevance of Na+-channel inactivation:
  • Conduction velocity and the effect of temperature changes
  • Recordings of bi- and mono-phasic action potentials using reversible nerve ligatures
  • Demonstrating the clinically most relevant impact of appropriate electrode positions
  • Understanding the difference between intra- and extracellular recordings

for details see Tutorial and Protocol form

For your own experiments you can download
a fully functioning DEMO Version

SimNeuron©

SimNeuron offers virtual laboratories for voltage- and current-clamp experiments in an easy to overlook lab design

  • towards a better understanding of the relations between ion currents and action potential generation
  • including a neuron editor showing the full set of the neuron parameters

Featured experiments:

  • Determine the threshold of action potential generation in thecurrent-clamp lab
  • Examine the effects of amplitude and duration of the current stimulus
  • Induction of a series of action potentials of different frequencies
  • Comparison of action potentials with local potentials and purely passive potential changes
  • Understanding the effects of the Na-channel blocker TTX and K+-channel blocker TEA
  • Display and explain the alterations of ionic conductances and currents during an action potential


  • Recordings of ion currents in the voltage-clamp lab with and without RC compensation
  • Application of the Na+-channel blocker TTX and K+-channel blocker TEA
  • Estimation of the activation (and inactivation) time constants
  • Determining the reversal potentials of Na+- and K+-currents. (tail currents)
  • Constructing current-voltage (I-V) curves and calculation of the voltage dependencies of ion channel activation

For the experts:

  • Use the Neuron Editor to examine the effects of different membrane parameters on the neuron’s sensitivity, e.g. with alterations of voltage- and time-dependencies of ion current activation and inactivation, leak conductances, ion concentrations, etc.

  • Examine how a neuron at constant resting potential can be transferred into a pacemaker neuron.

Pre-Settings:

In fully licensed versions there is the possibility to select to which specific features of the program the students shall have access. This can be done in so-called pre-settings window which you can open from the labs via the SETTINGS button in the switch bank. In demo versions the pre-settings are fixed with most functions enabled.